IBD肠外表现的新视角Daniel C Baumgart中文版VIP免费

炎症性肠病（IBD ）的肠外表现Daniel C. Baumgart, MD, PhD, FACP, AGAFProfessor of MedicineCharité Medical Center – Virchow HospitalMedical School of the Humboldt-University of Berlinwww.danielbaumgart.dewww.danielbaumgart.deBaumgart DC et al. Lancet. 2012 Nov 3;380(9853):1606-19.www.danielbaumgart.de流行病学具有相关肠外表现的比值比（95% 置信区间）Bernstein CN et al. Am J Gastro 2001;96:1116-1122.虹膜炎/ 葡萄膜炎原发性硬化性胆管炎（PSC ）强直性脊柱炎坏疽性脓皮病结节性红斑性别女男女男女男女男女男CD4.5 (2.2–9.4)p < 0.00013.1 (1.2–7.9)p < 0.054.7 (0.9–29.7)NS6.2 (1.0–37.2)NS3.9 (1.4–11.2)p < 0.0517.7 (7.0–44.5)p < 0.00012.9 (1.3–6.5)p < 0.054.0 (1.5–10.5)p < 0.011.8 (1.0–3.3)NS1.3 (0.4–4.2)NSUC8.6 (4.4–17.0)p < 0.00013.3 (1.2–9.2)p < 0.059.5 (2.7–32.9)p < 0.000130.3 (11.0–83.0)p < 0.00017.6 (2.0–28.3)p < 0.017.5 (2.9–19.0)p < 0.00012.9 (0.9–9.0)NS1.3 (0.4–3.6)NS2.2 (1.1–4.4)p < 0.052.5 (0.8–7.4)NSIBD6.3 (3.9–10.3)p < 0.00013.2 (1.6–6.4)p < 0.0017.3 (2.7–19.7)p < 0.000121.1 (9.2–48.7)p < 0.00015.0 (2.2–11.2)p < 0.000111.6 (6.1–22.1)p < 0.00012.9 (1.5–5.6)p < 0.012.2 (1.1–4.3)p < 0.052.0, (1.3–3.1)p < 0.011.8 (0.8–3.9)NS不同种族间肠外表现的多样性特征关节炎强直性脊柱炎葡萄膜炎结节性红斑坏疽性脓皮病PSC全部2.1%1.32.24.32.11.8白人1.7%1.51.63.41.91.3非洲人5.8% a1.78.1 c1.72.53.2西班牙人1.2% b01.2 d10.7 d,e2.43.0bp=<0.05,dp=<0.01,comparing Hispanics to African-Americanscomparing Hispanics to African-Americanswww.danielbaumgart.deap=<0.01, comparingAfrican-Americans to whitescp=<0.001, comparingAfrican-Americans to whitesep=<0.01, comparing Hispanics to whitesNguyen GC et al. Am J Gastro 2006;101:1012-1023.www.danielbaumgart.de多种肠外表现的预测因子与关联性克罗恩病的肠外表现预测因子( 多变量分析): 活动性疾病(OR=1.95, 95% CI = 1.17–3.23, p=0.01) 肠外表现家族史阳性 (OR=1.77, 95% CI=1.07–2.92,...