(包含有120种与关节、骨骼、肌肉等相关的疾病) 过敏性紫癜VIP免费

小儿风湿性疾病Rheumatoid Disease in Children XXX 医院 Connective tissue disease( 包含有120 种与关节、骨骼、肌肉等相关的疾病）过敏性紫癜 (anaphylactoid purpura)类风湿性关节炎 (JRA)风湿热 (rheumatic fever)川崎病 (kawasaki disease)系统性红斑狼疮 (systemic lupus erythematosis)皮肌炎 (dermatomyositis)硬皮病 (scleroderma)过敏性紫癜 Anaphylactoid purpura Henoch-Schonlein purpura Henoch-Schonlein syndrome（亨－舒综合征）DefinitionIgA 免疫复合物介导的白细胞碎裂性系统性小血管炎，病变主要累及皮肤、胃肠、关节及肾脏等部位Purple spots on the skinJoint painGastrointestinal symptomsRenal involvement General conditions较常见的微血管变态反应性出血性疾病春季上呼吸道感染后多发，也与昆虫叮咬或某些药物有关多发于2~8 岁的儿童男性较女性多见 病理毛细血管炎为主，亦可波及小静脉和小动脉血管壁可见胶原纤维肿胀和坏死，中性粒细胞浸润在皮肤和肾脏荧光显微镜下可见IgA 为主的免疫复合物沉积Common allergens includeMedications such as certain antibiotics, salicylic acid and thiazide diuretics)Pathogens bacterium/virus/parasite, such as group A strep, varicella, parvovirus and hepatitis BAn acute respiratory infectionCommon allergens includeFoods (such as berries, shellfish, fish, nuts, eggs, milk, and others)PollenAnimal dander (scales of shed skin)Insect bitesCertain vaccinations, such as for measles 临床表现皮肤症状：皮肤瘀点，对称分布、分批出现、大小不等、颜色深浅不一，可融合成片，多分布于臀部及下肢 关节症状：多发生在膝、踝、肘、腕等关节，关节腔可有渗液，但不留后遗症消化道症状：腹痛、呕吐，黑便或血便肾脏症状：肉眼血尿或镜下血尿、蛋白尿25 例过敏性紫癜的临床表现Purpura100%Arthritis75%Abdorminal pain65%Gastrointestinal bleeding30% Occult bleeding20% Gross bleeding10%Nephritis40% Microscopic haematuria10% Gross haematuria10% Proteinuria25% Nephrotic syndrome5% End-stage renal disease1%Recurrence of symptoms30%体征 Palpable purpura, ...