不均匀沉降在膝关节退变及内翻过程中机制的研究均匀沉降岩石黏土不均匀沉降不均匀沉降侧方失去支撑，发生不均匀沉降一侧负荷重，发生不均匀沉降• 随着年龄增长，人体骨质会发生一定程度疏松• 在体重负荷作用下，脊柱、膝关节、髋关节与踝关节等负重部位骨质均会发生不同程度沉降40岁50岁60岁>65 岁>80岁外侧沉降内侧沉降沉降前沉降后胫骨近端不均匀沉降胫骨近端为松质骨，负重面大，由于其内侧无骨性阻挡，外侧有腓骨支撑，根据生物力学、解剖学和临床研究，我们发现胫骨平台发生不均匀沉降胫骨平台不均匀沉降腓骨支撑是导致胫骨平台内外侧不均匀沉降的主要因素之一胫骨平台不均匀沉降导致内平台偏低，站立及行走时，股骨髁相对胫骨向内侧滑移，使膝关节内侧负荷进一步加重，形成恶性循环，加速了内侧平台的沉降继发膝关节力线内移、膝内翻畸形不均匀沉降膝内翻加速沉降腓骨支撑内侧负荷加重骨性关节炎恶性循环• 纳入膝关节内侧间室骨性关节炎患者行膝关节QCT 检查，分别测量腓骨、外侧平台、内侧平台和平台中部的骨密度影像学研究病例A 腓骨密度（mg/cm3）B 胫骨外侧平台骨密度C 胫骨内侧平台骨密度D 胫骨平台中部骨密度A-BA-CA-DC-BB-DC-D1124.284.4771.48-7.56119.8152.8131.8467.0112.0379.04273.3542.5441.975.4630.8131.3867.89-0.5737.0836.513121.5781.5193.4428.9340.0628.1392.6411.9352.5864.514130.7888.9687.3629.6141.8243.42101.17-1.659.3557.75561.223.1944.3-16.3938.0116.977.5921.1139.5860.69636.8621.6826.84-21.7315.1810.0258.595.1643.4148.57759.9-10.3337.86-22.970.2322.0482.848.1912.5760.76890.26-11.4154.92-1.83101.6735.3492.0966.33-9.5856.75989.736.6392.615.4553.07-2.9184.2555.9831.1887.1610101.5921.2138.313.7980.39-36.7297.8117.1117.41134.521131.44-2.9122.04-31.6234.359.463.0624.9528.7153.661228.920.9910.75-21.2427.9318.1750.169.7622.2331.991367.9829.1675.43-2.5738.82-7.4570.5546.2731.73781492.494376.596.3449.4915.986.1533.5936.6670.251598.219.6771.01-31.4378.5327.19129.6351.3451.1102.441682.5727.2942.82-53.1255.2839.75135.6915.5380.4195.941769.18-31.27108.5-43.17100.45-39.32112.35139.7711.9151.671866.873.6829.77-42.963.1937.1109.7726.0946.5872.6719113.7510.6464.73-22.04103.1149.02135.7954.0932.6886.772094.620.4736.21-10.0474.135...
