治疗心血管疾病药物药理基础和临床应用要点VIP免费

2 0xx治疗心血管相关疾病药物药理基础和临床应用要点 Basic Cardiac Pharmacology xxxxxxxxxxxxWeb DesignSocial MediaCONTENTS• Common Lipid Lowering Medications常用降脂药物 • Classes of Diabetic Medications常用降糖药物• Antihypertensive Medications 常用降血压药物1Common Lipid Lowering Medications常用降脂药物 Drug Class药物分类Agents and Daily Doses 药物和每日剂量Lipid/Lipoprotein Effects 脂质/ 脂蛋白的影响 Side Effects副作用Contradictions禁忌症HMG CoA reductase inhibitors (statins) HMG-CoA还原酶抑制剂（他汀类药物）Lova 洛伐他丁Prava 匹伐他丁, Simva 辛伐他丁, Fluva 氟伐他丁, Atorva 阿托伐他丁, -statinLDL 18-55%HDL 5-15%TG 7-30%Myopathy肌病Increased liver enzymes 肝酶升高 Absolute: Liver绝对的：肝Relative: drugs相对的：药物Bile Acid Sequestrants 胆汁酸 螯合剂类 Cholestyramine 消胆胺 Colestipol 降脂宁Colesevelam 考来维仑 LDL - 15-30%HDL + 3-5%TG 0 GI distress 胃肠道不适 Constipation 便秘Decreased absorb drugs 减少吸收的药物 Absolute: dysbeta lipoproteinTG > 400 (200)绝对：dysbeta 脂蛋白 TG > 400 （200 ） Nicotinic Acid 烟酸Immediate release and sustained 立即释放并维持 LDL - 5- 25%HDL + 15 - 35%TG - 20 – 50%Flushing 面潮红Hyperglyc 高血糖Gout 痛风GI / Hepatox 肠道/ 肝毒Absolute: 绝对的-Liver Dz 肝病-Gout 痛风Relative: 相对的- DM, PUD 糖尿病Fibric acids纤维酸Gemfibrozil 吉非罗齐 Fenofibrate 非诺贝特 Clofibrate 氯贝丁酯 LDL - 5- 20%HDL + 10 - 20%TG - 20 – 50%Dyspepsia 消化不良 Gallstones 胆结石Myopathy 肌病 Absolute: 绝对的- Severe Renal 肾严重问题- Severe Liver 肝严重问HMG CoA Reductase Inhibitors,HMG-CoA 还原酶抑制剂 • Statins 他汀类药物 • Powerful LDL lowering drugs 强大降低低密度脂蛋白的药物 • Statin therapy reduces the risk for acute coronary syndromes, procedures and other outcomes in both primary and secondary prevention 他汀类药物治疗可以降低急性冠脉综合征的风险，在原发性...